Principal Scientist, CAR Screening and Lead Selection (CGM)
Company: 6084-Janssen Research & Development Legal Enti
Location: Cambridge
Posted on: April 5, 2026
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Job Description:
At Johnson & Johnson, we believe health is everything. Our
strength in healthcare innovation empowers us to build a world
where complex diseases are prevented, treated, and cured, where
treatments are smarter and less invasive, and solutions are
personal. Through our expertise in Innovative Medicine and MedTech,
we are uniquely positioned to innovate across the full spectrum of
healthcare solutions today to deliver the breakthroughs of
tomorrow, and profoundly impact health for humanity. Learn more at
jnj.com As guided by Our Credo, Johnson & Johnson is responsible to
our employees who work with us throughout the world. We provide an
inclusive work environment where each person is considered as an
individual. At Johnson & Johnson, we respect the diversity and
dignity of our employees and recognize their merit. Job Function:
Discovery & Pre-Clinical/Clinical Development Job Sub Function:
Biological Research Job Category: Scientific/Technology All Job
Posting Locations: Cambridge, Massachusetts, United States of
America Job Description: About Innovative Medicine: Our expertise
in Innovative Medicine is informed and inspired by patients, whose
insights fuel our science-based advancements. Visionaries like you
work on teams that save lives by developing the medicines of
tomorrow. Join us in developing treatments, finding cures, and
pioneering the path from lab to life while championing patients
every step of the way. Learn more at
https://www.jnj.com/innovative-medicine We are searching for the
best talent for a Principal Scientist, CAR Screening and Lead
Selection (CGM), to be based in Cambridge, MA. Purpose: We are
seeking an experienced and highly motivated Principal Scientist to
join our CAR Screening and Lead Selection team focused on advancing
next-generation cell therapies. The Principal Scientist will work
with team leadership to develop and execute the scientific strategy
to select CAR-T candidates and generate data sets that drive
pipeline progression. This role offers the opportunity to work
cross-functionally in a dynamic, fast-paced environment with
cutting-edge technologies. You will be responsible for: Advance
multiple pipeline programs by designing, executing, and analyzing
complex in vitro assays that stratify lead CAR-T constructs based
on phenotype and function. Contribute to strategic project
planning; integrating results and departments goals into next
steps. Subject matter expert for specified research projects and/or
laboratory techniques. Uses new developments and technologies to
improve scientific workflows. Thorough analysis of complex data
sets, effectively communicates impact of experimental results to
leadership and key stakeholders. Collaborate closely with
colleagues in discovery, process development, and therapeutic area
teams to align priorities and share data. Contribute to broader
team experimental designs, scientific strategy discussions and
provide guidance and support to junior team members. Follow best
practice lab operations for safety, data integrity, and
reproducibility. Maintain meticulous records of experimental
design, data, and analysis using electronic lab notebook (ELN).
Qualifications: PhD in immunology, cell biology, or a related field
with 4 years of relevant industry or experience; OR a Master’s or
Bachelor’s degree with 6-8 years of experience will also be
considered. Demonstrated experience with project planning and CAR T
candidate selection. Takes initiative to advance scientific
capabilities; challenges status quo to improve workflows and
technical skillset. Extensive hands-on experience with
multiparameter flow cytometry, including panel design, sample
preparation, acquisition, and data analysis. Experienced with
spectral flow cytometry is preferred. Experience with intracellular
cytokine staining and cytokine arrays, such as MSD or comparable.
Proficiency in IncuCyte-based assays or comparable real-time
cytotoxicity platforms. Demonstrated expertise using ELN systems
for experimental documentation, experience with Benchling a plus.
Advanced skills in data analysis and presentation using GraphPad
Prism, Spotfire or similar software. Strong problem-solving skills
and the ability to independently drive projects while working
collaboratively. Excellent written and verbal communication skills.
This role may require up to 10% travel. Johnson & Johnson is an
Equal Opportunity Employer. All qualified applicants will receive
consideration for employment without regard to race, color,
religion, sex, sexual orientation, gender identity, age, national
origin, disability, protected veteran status or other
characteristics protected by federal, state or local law. We
actively seek qualified candidates who are protected veterans and
individuals with disabilities as defined under VEVRAA and Section
503 of the Rehabilitation Act. Johnson and Johnson is committed to
providing an interview process that is inclusive of our applicants’
needs. If you are an individual with a disability and would like to
request an accommodation, please email the Employee Health Support
Center (ra-employeehealthsup@its.jnj.com) or contact AskGS to be
directed to your accommodation resource. Required Skills: Preferred
Skills: Analytical Reasoning, Biochemistry, Biotechnology,
Chemistry, Manufacturing, and Control (CMC), Clinical Research and
Regulations, Clinical Trial Designs, Coaching, Critical Thinking,
Drug Discovery Development, Emerging Technologies, Molecular
Diagnostics, Organizing, Pharmacovigilance, Presentation Design,
Process Improvements, Productivity Planning, Scientific Research
The anticipated base pay range for this position is : $117,000.00 -
$201,250.00 Additional Description for Pay Transparency: Subject to
the terms of their respective plans, employees are eligible to
participate in the Company’s consolidated retirement plan (pension)
and savings plan (401(k)). Subject to the terms of their respective
policies and date of hire, employees are eligible for the following
time off benefits: Vacation –120 hours per calendar year Sick time
- 40 hours per calendar year; for employees who reside in the State
of Colorado –48 hours per calendar year; for employees who reside
in the State of Washington –56 hours per calendar year Holiday pay,
including Floating Holidays –13 days per calendar year Work,
Personal and Family Time - up to 40 hours per calendar year
Parental Leave – 480 hours within one year of the
birth/adoption/foster care of a child Bereavement Leave – 240 hours
for an immediate family member: 40 hours for an extended family
member per calendar year Caregiver Leave – 80 hours in a 52-week
rolling period10 days Volunteer Leave – 32 hours per calendar year
Military Spouse Time-Off – 80 hours per calendar year For
additional general information on Company benefits, please go to: -
https://www.careers.jnj.com/employee-benefits
Keywords: 6084-Janssen Research & Development Legal Enti, Lowell , Principal Scientist, CAR Screening and Lead Selection (CGM), Science, Research & Development , Cambridge, Massachusetts
